PhD Studentship: Understanding Intrinsically Disordered Protein-Protein Interactions Using Peptidomimetics

Overview

This PhD studentship focuses on understanding and modulating protein-protein interactions by targeting intrinsically disordered regions. The research involves exploring backbone amide modification across a series of peptidomimetics designed to inhibit beta-strand-mediated protein-protein interactions. The project utilizes N-alkylation and amide to thioamide substitution, employing automated solid-phase peptide synthesis alongside structural biophysical methods such as fluorescence anisotropy, surface plasmon resonance isothermal titration calorimetry, and cutting-edge 2D NMR experiments to examine conformational ensembles and binding mechanisms.

What you get

This is a full-time, fixed-term PhD position supervised by Professor Andy Wilson and Professor Teresa Carlomagno within the School of Chemistry at the University of Birmingham. The studentship is part of the Midlands Integrated Biosciences Training Partnership, funded by the BBSRC, and conducted in partnership with the University of Warwick, University of Birmingham, Aston University, Harper Adams University, Coventry University, and the University of Leicester.

Key dates

The closing date for applications is November 23, 2026.