PhD Studentship: Developing a variant effect predictor for multiple missense variants in the same protein molecule to aid clinical interpretation
Overview
The University of Exeter, through its Department of Clinical and Biomedical Sciences, offers a PhD studentship funded by the EPSRC Engineering and Physical Sciences Research Council. This doctoral research project focuses on developing a variant effect predictor for multiple missense variants located within the same protein molecule to support clinical interpretation in rare genetic diseases.
Requirements
The project requires interdisciplinary research involving machine learning methods and in silico three-dimensional protein structure modelling, utilizing genetic, biochemical, and functional datasets. The supervisory team includes researchers from the University of Exeter, the University of Edinburgh, and Imperial College London who provide expertise in genetics, bioinformatics, and protein structure.
What you get
The studentship provides coverage for tuition fees along with an annual stipend of £21,805 for the 2026/7 period. The position is structured as a full-time, fixed-term contract based on site in the United Kingdom.
Key dates
The closing date for applications is 2026-12-08.
About University of Exeter
The University of Exeter is a public research university in the West Country of England, based mainly in Exeter, Devon, with further campuses in Cornwall. Its origins lie in St Luke's College (1838), the Exeter schools of Art and Science, and the Camborne School of Mines. A royal charter in 1955 created the university. It is a member of the Russell Group of research-intensive UK universities.
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