PhD Studentship: Decoding the rules of human gene interaction networks using combinatorial functional genomics

Overview

This studentship focuses on a functional genomics project aimed at decoding the rules of human gene interaction networks through combinatorial technologies. While large-scale sequencing has identified numerous genetic variants linked to traits and diseases, understanding their biological influence remains challenging because genes function within interconnected networks. The project builds upon multiplexed Variable Dose Analysis technology to map genetic interactions in human cells, providing insights into health, disease, and how gene combinations determine cell behavior.

What you get

The successful candidate receives funding covering tuition fees along with an annual stipend of £21,805 per annum for the 2026/7 period. The student joins a collaborative research environment with access to advanced facilities for high-throughput screening, live-cell imaging, single-cell sequencing, and computational methods. Training encompasses genetic perturbation technologies, advanced microscopy, single-cell genomics, computational analysis, and statistical modelling.

Requirements

Applicants should be prepared to undertake an interdisciplinary research project that integrates functional genomics, molecular genetics, imaging, bioinformatics, statistics, and data science. The work involves adapting multiplexed Variable Dose Analysis for human cells, integrating the approach with either live-cell microscopy or single-cell sequencing, and applying the platform to investigate genetic interactions related to the tumour suppressor NF1.

Key dates

The closing date for applications is 2026-12-08.